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Pentosan Equine Injection

Anti-inflammatory, anti-arthritic & Chondroprotective Agent for use in horses

Composition
Contains: Sodium Pentosan polysulfate 250 mg/mL

Features and Benefits
Sodium pentosan polysulfate (PPS) is a linear polymer prepared from xylan, a complex hemicellulose extract of plant (Beechwood) origin. PPS is one of the sulfated heparinoid compounds the heparin-like anti-coagulant effects have been reduced and the anti-inflammatory, fibrinolytic, and tissue trophic effects have been enhanced.

PENTOSAN EQUINE actively reverses the effects of osteoarthritis in the joints via a series of actions, including:

• Stimulating Chondrocyte Metabolism -resulting in increased production of proteoglycans and healthy cartilage matrix. PPS stimulates synovial fibroblasts to produce increased amounts of high molecular weight hyaluronic acid which results in an increased production of normally viscous joint fluid. Improving the fluid volume and consistency results in more effective joint lubrication and stabilisation, which limits further cartilage damage.
• Anti-inflammatory Activity -PPS has an inhibitory action on all mediators of the 6 mL sterile Injection arachidonic acid cascade. PPS also inhibits the lysosomal catabolic enzymes hyaluronidase, histamine, cathepsin B, and polymorphonuclear elastase. PPS exerts a specific inhibitory effect on mediators implicated in the degradation of cartilage matrix components, preserving the cartilage and preventing the release of the highly inflammatory mediators, thus relieving pain and inflammation.
• Fibrinolysis and Lipolysis - PPS is strongly fibrinolytic, stimulating the release of plasminogen activator, and promoting the dissolution of thrombi and fibrin deposits in synovial tissues and subchondral blood vessels PPS also mobilises lipids and cholesterol in synovial and subchondral blood vessels, which have been implicated in the pathogenesis of osteoarthritis in older animals These effects combine to increase the prefusion to the joint, which stimulates cartilage healing and repair.

PENTOSAN EQUINE is a sophisticated approach to the long term management of osteoarthritis in horses.

PENTOSAN EQUINE is equally effective by both intramuscular and intra-articular injection. Unlike traditional treatments, the unique effects of PENTOSAN EQUINE promote healing and the restoration of a healthy joint, in addition to having a safe anti- inflammatory effect.

PENTOSAN EQUINE is NOT a non-steroidal anti-inflammatory drug like Phenylbutazone, or the cortisones (both of which have damaging effects on joints with prolonged use). PENTOSAN EQUINE does not suppress joint cartilage healing and repair.

Rather than simply masking pain, PPS directly stimulates joint healing and repair.

Anti-inflammatory agents, corticosteroids and NSAIDs all relieve the symptoms of osteoarthritis but DO NOT ALTER THE DISEASE PROCESS. Both hydrocortisone and NSAIDs have a marked inhibitory effect on the biosynthesis of the components of the extracellular matrix of cartilage, which limits the early healing response of cartilage to injury.

Indications
Non-infectious inflammatory joint disease, traumatic arthritis, degenerative cartilaginous joint disease, osteoarthritis and osteochondrosis dessicans in horses.

Contraindications
Do Not Use in horses with clotting defects, traumatic haemorrhage, infection, renal or hepatic failure, or within 48 hours of surgery.

Dosage & Administration
Pentosan Equine injection should be administered by i/m or i/a injection at a dosage of 3mg/kg b.w.(6mL vial/500kg horse) at 5-7 day intervals for 4 injections. For maximum effect tissues should be exposed to the drug over an extended period of time. In approximately 80% of accurately diagnosed conditions a marked improvement will be noted after the second injection. Improvement for up to 6 months following a course of 4 injections can be expected.

Withholding time
Nil

Presentation
6mL sterile single dose glass vial. Provides one dose (1.5 g) for a 500kg horse at the recommended dose rate (3 mg/kg)

Storage
Store at 2 - 8°C (Refrigerate. Do not freeze). Protect from light.

Registration
Restricted Veterinary Medicine – Registered pursuant to the ACVM Act 1997 No. A9284.
See www.nzfsa.govt.nz/acvm for registration conditions.

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