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Prescription Products

SedaMed Medetomine Injection

Sedative, analgesic for use in the restraint of dogs and cats
Active constituent: 1 mg/mL Medetomidine Hydrochloride

Action

Medetomidine, 4{1-(2,3-dimethylphenyl)ethyl}-1H-imidazole, is a potent, selective and specific alpha-2 adrenoceptor agonist. Alpha-2 adrenoceptor activation by medetomidine induces a dose-dependent decrease in the release and turnover of noradrenaline in the central nervous system which is manifested as sedation, analgesia and bradycardia. In the periphery, medetomidine causes vasoconstriction by activating postsynaptic alpha-2 adrenoceptors in the vascular smooth muscle. Thus the blood pressure initially increases after medetomidine injection due to an increase in systemic vascular resistance. The pressure reverts to normal or slightly below within 1 to 2 hours. The respiratory frequency may transiently be lowered.

Indications

Dogs	sedative, analgesic for use in the restraint of dogs for clinical examinations and procedures, minor surgery and pre-anaesthesia
Cats	sedative for restraint

Contraindications

The use of SedaMed in pregnancy has not been monitored in sufficient animals and is, therefore, not recommended. SedaMed should not be used in conjunction with sympathomimetic amines.

Toxicity/Antidote

In the case of overdosage, atipamezole can be used, The administration of anticholinergic agents (atropine or glycopyrrolate) to treat bradycardia either simultaneously with medetomidine or following medetomidine could lead to adverse cardiovascular effects.

Dosage

After withdrawal of the first dose, use remaining product within 3 months after opening. For intramuscular or intravenous injection in dogs and intramuscular injection in cats.

Animal	Effect	Dose µg/kg	Quantity
Dog	Slight sedation	10-30	0.1 - 0.3 mL/10 kg
	Moderate to deep sedation and analgesia	30-80	0.3 - 0.8 mL/10 kg
	Pre-anaesthesia	10-20	0.1 - 0.2 mL/10 kg
Cat	Moderate sedation	50-100	0.25 - 0.5mL/5kg
Cat	Deep sedation	100-150	0.5 -0.75 mL/5kg

To get an equal effect, the higher recommended doses per kg body weight have to be used in small dogs compared to large dogs.

Maximal effect is obtained within 10 to 15 minutes. Duration of the clinically useful effect is dose related - 30 to 120 minutes (sedation). 30 to 150 minutes (analgesia). The dose can be repeated if necessary. The duration of analgesia is generally shorter than the duration of sedation. Both analgesic effect and sedative effect are reversed with the use of atipamezole injection.

Side Effects

Due to the mechanism of action of SedaMed, heart rate and body temperature decrease. Treated animals should be kept warm in an even temperature for 12 hours after sedation. Blood pressure will initially increase and then return to normal or slightly below. This is accompanied by a compensatory decrease in heart rate. Some dogs and most cats will vomit, (particularly if recently fed), 5 to 10 minutes post-injection. Some cats may also vomit at recovery. Occasionally muscle jerking in limbs has been observed.

Special Precautions

Care should be taken with the use of SedaMed in animals with cardiovascular, respiratory, liver and kidney disease, hypotension, shock or in poor general health. The concomitant use of other CNS depressants may potentiate the depressant effects of either product, and appropriate dose adjustment should be made. Wipe off excessive spillage on skin of animals.

Withholding Times	Nil
First Aid / Poisoning	If poisoning occurs, contact a doctor or Poisons Information Centre (NZ) 0800 764 766
Pack Size & Presentation	10mL
Storage	Store below 25°C (air conditioning). Do not freeze.

Registration

SEDAMED MEDETOMIDINE INJECTION is a Prescription Animal Remedy (P.A.R) class II, for use only under the authority or prescription of a veterinarian. Registered pursuant to the ACVM Act 1997 No. A9745 P.A.R. See www.nzfsa.govt.nz/acvm for registration conditions.

Registered to:

Nature Vet Pty Ltd
11 Moores Rd, Glenorie, NSW, Australia 2157